demcon-convergence-markets-pharmaceuticals

pharmaceuticals & biotech

In the precision-driven pharmaceuticals and biotech market, several factors are considered critical across R&D manufacturing and the regulatory domain. These include things like product safety and compliance, but also (quality) control and traceability. All to support the efficient and robust scale-up of Active Pharmaceutical Ingredients (APIs), from milligrams to grams, and ultimately to kilograms. This is where our engineered membrane equipment comes in.

engineered systems for critical biotech challenges.

We develop custom membrane testing systems and fluid handling solutions that directly support the critical necessities of this market. Our solutions are used for:

  • Validation (custom filter integrity testing)
  • Protein and enzyme concentration
  • Clarification of cell lysates
  • Buffer exchange using Diafiltration
  • Virus filtration

We apply technologies such as ultrafiltration (UF), microfiltration (MF), and nanofiltration (NF), and can integrate third party membranes into systems tailored for research centers, biotech labs and manufacturing plants/ production environments.

demcon-convergence-pharmaceuticals
our systems

specifically designed to your needs.

Our portfolio consists of baseline solutions that we can tailor specially to your unique requirements and are not off the shelf. The level of customization in terms of hardware and software really sets us apart as we develop the most optimized solution to your challenge

Tangential Flow Filtration (TFF) systems

A tangential flow filtration (TFF) system is a membrane-based separation technique used to concentrate, purify, or fractionate biomolecules in solution. Unlike dead-end filtration, TFF directs the feed solution tangentially across the membrane surface, minimizing fouling and allowing continuous operation. The system uses transmembrane pressure to drive solvent and small solutes through the membrane while retaining larger molecules. Flow dynamics and membrane characteristics determine separation performance, making TFF suitable for scalable bioprocessing applications. Our systems are designed to minimize hold-up volume and eliminate dead zones, ensuring maximum product recovery, especially critical for high-value biologics

Liquid-Liquid Porometry (LPP) systems

A liquid-liquid porometer is a specialized instrument used to characterize the pore structure of membranes or porous materials, particularly in the submicron range. It differs from gas-liquid porometry by using two immiscible liquids instead of a gas and a liquid. The technique is based on displacement of a wetting liquid from the pores of a membrane by a second, immiscible liquid under pressure. The pressure required to displace the wetting liquid from the pores is related to the pore size via the Young-Laplace equation.

Filter Integrity Testers

Filter Integrity Testers are used to verify the performance and reliability of membrane filters, especially in critical applications like pharmaceuticals and biotech. These testers ensure that filters were intact, properly installed, and functioning within specifications during filtration. Our test methods include Bubble Point test, Diffusion test, Pressure Hold test and the Water Intrusion test.

craftmanship you can trust.

Whether you're developing biologics, vaccines, or advanced therapies, Demcon convergence delivers craftsmanship, flexibility, and process control you can trust.